Paclitaxel

Name: Paclitaxel
SKU: 0

CAS No.:33069-62-4
Molecular Formula：C47H51NO14
Molecular Weight: 853.92

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product description

Paclitaxel, a natural product isolated from the bark of the Pacific yew, is effective in treating refractory metastatic ovarian cancer. Unlike any other antineoplastic agents, paclitaxel appears to have several possible mechanisms of action, including an antimicrotubule action through the promotion of tubulin polymerization and stabilization of microtubules, thereby, halting mitosis and promoting cell death.

Chemical Properties

Property	Value
Melting point	213 °C (dec.)(lit.)
Alpha	D20 -49° (methanol)
Boiling point	774.66°C (rough estimate)
Density	0.200
Refractive index	-49 ° (C=1, MeOH)
Fp	9℃
Storage temp.	2-8°C
Solubility	Methanol: 50 mg/mL, clear, colorless
Form	Powder
Pka	11.90±0.20(Predicted)
Color	White
Water Solubility	0.3mg/L(37 ºC)
λmax	227nm(MeOH)(lit.)
Merck	14,6982
BRN	1420457
Stability	Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey	RCINICONZNJXQF-MZXODVADSA-N
LogP	3.950 (est)
CAS DataBase Reference	33069-62-4(CAS DataBase Reference)
EPA Substance Registry System	Paclitaxel (33069-62-4)

Safety Information

Property	Value
Hazard Codes	Xn
Risk Statements	37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22
Safety Statements	22-26-36/37/39-45
RIDADR	1544
WGK Germany	3
RTECS	DA8340700
F	10-21
HazardClass	6.1(b)
PackingGroup	III
HS Code	29329990
Hazardous Substances Data	33069-62-4(Hazardous Substances Data)
Toxicity	LD50 intraperitoneal in mouse: 128mg/kg

Product Usage

Paclitaxel is a potent antineoplastic agent originally derived from the Pacific yew tree, widely regarded as a cornerstone in clinical oncology. Its primary application is the treatment of various malignancies, including breast, ovarian, and non-small cell lung cancers, by stabilizing microtubules and inhibiting cell division. In the pharmaceutical industry, it is formulated into sophisticated drug delivery systems, such as albumin-bound particles (nab-paclitaxel), to enhance solubility and reduce side effects. Beyond systemic chemotherapy, Paclitaxel is extensively used in the medical device sector, specifically as a coating for drug-eluting stents and balloons to prevent restenosis in cardiovascular procedures. Its critical role extends to biomedical research, where it serves as a fundamental tool for studying cytoskeleton dynamics and developing next-generation targeted cancer therapies.

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Delivery Time

Inventory 2-3 working days New manufacturing 7-10 working days

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2. By Sea, usual and economy.
3. By Train, suit for middle Asia countries.
4. By Express, suit for small package.
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